In dogs, hypoadrenocorticism has been diagnosed in many breeds. Vague symptoms which wax and wane can cause delay in recognition of the presence of the disease.  Female dogs appear more affected than male dogs, though this may not be the case in all breeds.  The disease is most often diagnosed in dogs which are young to middle aged, but it can occur at any age from 4 months to 14 years.  Treatment of hypoadrenocorticism must replace the hormones (cortisol and aldosterone) which the dog cannot produce itself.  This is achieved either by daily treatment with fludrocortisone, or monthly injections with desoxycorticosterone pivalate (DOCP) and daily treatment with a glucocorticoid, such as prednisone.  Several follow-up blood tests are required so that the dose can be adjusted until the dog is receiving the correct amount of treatment, because the medications used in the therapy of hypoadrenocorticism can cause excessive thirst and urination if not prescribed at the lowest effective dose.  In anticipation of stressful situations, such as staying in a boarding kennel, dogs require an increased dose of prednisone.  Lifelong treatment is required, but the prognosis for dogs with hypoadrenocorticism is very good.