On November 18, 2006, she performed at the Home Depot Center in Carson, California, for VH1's Save the Music Battle of the High School Marching Bands competition, marking her first ever stadium performance in front of thousands of people. In addition, as part of her contract with Disney, Palmer sang the songs "It's My Turn Now" and "Jumpin'" featured in the Disney Channel Original Movie Jump In!, in which she stars as Mary, the love interest to Corbin Bleu's character. In 2006, Palmer was featured in the music video for the Ludacris and Mary J. Blige song "Runaway Love", in which she starred as a pregnant 11-year-old girl. That same year, she recorded a song entitled "Tonight" which was featured as the first song in the end credits of Night at the Museum. Besides focusing on her music career, Palmer had the lead role in the 2006 film Akeelah and the Bee, in which she played a bright 11-year-old who comes from a poor neighborhood and competes in the Scripps National Spelling Bee. Palmer also had a supporting role in the 2006 film Madea's Family Reunion.