The lateral corticospinal tract is responsible for the motor pathway of the pronator quadratus. This tract begins in the precentral gyrus of the motor cortex where a signal is transmitted from the upper motor nerve through the progression tracts of the internal capsule and through the cerebral peduncles of the midbrain. It decussates in the medulla and travels down the lateral corticospinal tract in the lateral column of the spinal cord. It then decussates in the spinal cord and synapses at the anterior horn to the lower motor neurons of the skeletal muscles. The cuneate fasciculus tract is responsible for the sensation of the pronator quadratus position and movement, deep touch, visceral pain, and vibration. This tract begins in the dorsal nerve root where the signal is transmitted through the dorsal horn and up the posterior column of the spinal cord. It synapses with an interneuron in the gracile nucleus. It then decussates in the medial lemniscus of the medulla, travels through the cuneate nucleus and through the medial lemniscus of the midbrain to synapse in the thalamus. It synapses with a third order neuron and transmits the signal to the postcentral gyrus of the somesthetic cortex. This could apply to any muscle in the upper limb and not specific to this muscle.