Scott landed a lead role as a police officer in Southland Tales (2007), where he reunited with Dwayne "The Rock" Johnson, with whom he had previously worked in The Rundown (2003). The two performed several skits, including scenes from The Matrix Reloaded, which are on The Matrix Reloaded DVD. He has also hosted Saturday Night Live and appeared as a guest co-host on Live with Regis and Kelly. Scott appeared as John Farley in Mr. Woodcock (2007) and as Jeff Nichols in Trainwreck: My Life as an Idiot (2007). His next film, Role Models (2008) was a commercial success and grossed over $92 million at the box office worldwide. The film was met with positive reviews and was selected as one of the best films of 2008 by Eye Weekly. He voiced the character Crash in Ice Age: The Meltdown and reprised his role in its sequel Ice Age: Dawn of the Dinosaurs (2009) and Ice Age: Continental Drift (2012). He appeared in the action-comedy film Cop Out (2010) alongside Bruce Willis, Tracy Morgan and Kevin Pollack. To prepare for his role in Cop Out, Scott gained weight and stopped working out for six months. In 2011, Scott starred in the Canadian sports comedy film Goon as Doug 'The Thug' Glatt. The film was a critical success and made $6. 7 million at the worldwide box office. In 2012, he starred in Movie 43 in the segment 'Happy Birthday'. In April 2012, Scott received an honorary medal from Trinity College’s Philosophical Society. In October 2013, Scott guest-starred in an episode of the FX television series It's Always Sunny in Philadelphia, playing Mac's cousin named Country Mac.